Description
Product Characteristics:
The members of the G-protein-coupled receptor family are distinguished by their slow transmitting response to ligand binding. These seven transmembrane proteins include the adrenergic, serotonin and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. b-adrenergic bound to adrenaline activates adenylyl cyclase, while a2-adrenergic receptor bound to adrenaline inhibits adenylyl cyclase. Like the a2-adrenergic receptor, serotonin receptor functions are also mediated by G proteins that inhibit the activity of adenylyl cyclase. The serotonin receptors have been classified into several categories, designated SR-17 (5HT17). Subtypes within the SR-1 group include SR-1A, -1B, -1D, -1E and -1F.
Subcellular location: Cell membrane
Synonyms: 5 HT 1F, 5 HT1F, 5 hydroxytryptamine serotonin receptor 1F, 5 hydroxytryptamine 1F receptor, 5 hydroxytryptamine receptor 1E beta, 5 hydroxytryptamine receptor 1F, 5 hydroxytryptamine serotonin receptor 1E beta, 5 hydroxytryptamine serotonin receptor 1F, 5HT 1F, 5HT1F, HTR 1F, HTR1EB, HTR1EL, HTR1F, MR 77, MR77, Serotonin receptor 1E beta, Serotonin receptor gene, 5HT1F_HUMAN.
Target Information: This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity